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| 桃核承气汤联合中医灌肠对老年糖尿病肾病患者外周血T细胞亚群及血液流变学的影响 |
| Effect of Taohe Chengqi Decoction combined with traditional Chinese medicine enema on peripheral blood T cell subsets and hemorheology in elderly patients with diabetic nephropathy |
| 投稿时间：2023-10-18 修订日期：2023-10-18 |
| DOI： |
| 中文关键词: 桃核承气汤 中医灌肠 糖尿病肾病 T细胞亚群 血液流变学 肾功能 |
| 英文关键词: Taohe Chengqi Decoction TCM enema Diabetic nephropathy T cell subset Hemorheology Renal function |
| 基金项目: |
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| 中文摘要: |
| 目的? 探讨桃核承气汤联合中医灌肠对老年糖尿病肾病(DN)患者外周血T细胞亚群及血液流变学的影响。方法 选取2019年1月～2023年3月华中师范大学医院收治的243例DN患者,简单随机化分为3组,各81例。3组均予以西医综合治疗,在此基础上,灌肠组加用中医灌肠,汤剂组加用桃核承气汤,联合组加用桃核承气汤联合中医灌肠,均治疗2个月。比较3组总有效率、中医症候积分、T细胞亚群(CD3+、CD4+/CD8+)水平、肾功能指标[血肌酐(SCr)、血尿素氮(BUN)、内生肌酐清除率、24 h尿蛋白定量]、血清转化生长因子-β1(TGF-β1)、纤溶酶原激活物抑制因子-1(PAI-1)水平、血液流变学指标[血浆黏度、红细胞比容(HCT)、红细胞聚集指数(EAI)]及不良反应。结果? 联合组治疗后总有效率(92.59%)较汤剂组(69.14%)、灌肠组(72.84%)高,中医症候积分较汤剂组、灌肠组低(P＜0.05)；联合组治疗后CD3+、CD4+/CD8+、内生肌酐清除率较汤剂组、灌肠组高,SCr、BUN、24 h尿蛋白定量、TGF-β1、PAI-1、血浆黏度、HCT、EAI水平较汤剂组、灌肠组低(P＜0.05)；3组不良反应发生率比较,无显著差异(P＞0.05)。结论 桃核承气汤联合中医灌肠治疗老年DN,可改善患者症状体征,保护肾功能,纠正免疫失衡状态,疗效显著,安全可靠,其机制可能与下调TGF-β1、PAI-1及改善血液流变学有关。 |
| 英文摘要: |
| Objective To investigate the effects of Taohe Chengqi Decoction combined with traditional Chinese medicine enema on peripheral blood T cell subsets and hemorheology in elderly patients with diabetic nephropathy (DN). Methods A total of 243 patients with DN admitted to Central China Normal University Hospital from January 2019 to March 2023 were randomly divided into 3 groups, 81 cases each. All the three groups were treated with Western medicine. On this basis, the enema group was supplemented with traditional Chinese medicine enema, the decoction group was supplemented with Taohe Chengqi Decoction, and the combined group was treated with Taohe Chengqi Decoction combined with traditional Chinese medicine enema for treatment for 2 months. Compare the total effective rate, TCM syndrome scores, T cell subsets (CD3+, CD4+/CD8+) levels, renal function indicators [serum creatinine (SCr), blood urea nitrogen (BUN), endogenous creatinine clearance, 24 h urine) Protein quantification], serum transforming growth factor-β1 (TGF-β1), plasminogen activator inhibitor-1 (PAI-1) level, hemorheology index [plasma viscosity, hematocrit (HCT), red blood cells Aggregate Index (EAI) and adverse reactions. Results The total effective rate (92.59%) in the combined group was higher than that in the decoction group (69.14%) and enema group (72.84%). The TCM syndrome score was lower than that in the decoction group and the enema group (P<0.05). CD3+, CD4+/CD8+, endogenous creatinine clearance was higher than decoction group and enema group, SCr, BUN, 24 h urine protein quantitation, TGF-β1, PAI-1, plasma viscosity, HCT, EAI levels were higher than decoction group. The enema group was low (P<0.05); there was no significant difference in the incidence of adverse reactions in the three groups (P>0.05). Conclusion Taohe Chengqi Decoction combined with traditional Chinese medicine enema for the treatment of senile DN can improve symptoms and signs, protect renal function, correct immune imbalance, and has a remarkable and safe effect. The mechanism may be related to down-regulating TGF-β1, PAI-1 and improving blood flow. It is related to change. |
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