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| 中药灌洗配合纳米银抗菌水凝胶治疗阴道炎的效果及不良反应观察 |
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| 投稿时间：2023-10-16 修订日期：2023-10-16 |
| 中文关键词: 中药灌洗 纳米银抗菌水凝胶 阴道炎 不良反应 白细胞介素-6 转化生长因子-β1 |
| 英文关键词: Traditional Chinese medicine irrigation Nano silver antibacterial hydrogel Vaginitis Adverse reactions Interleukin-6 Transforming growth factor- β 1 |
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| 中文摘要: |
| 目的:探讨中药灌洗联合纳米银抗菌水凝胶对阴道炎的治疗效果,并观察不良反应发生情况。方法:2020年4月到2023年2月选择在本院诊治的阴道炎患者94例作为研究对象,根据1:1随机数字表法把94例患者分为研究组47例与对照组47例。对照组给予甲硝唑治疗,研究组给予中药灌洗配合纳米银抗菌水凝胶治疗,研究组与对照组都治疗观察8周,记录疗效与不良反应发生。结果:研究组与对照组治疗8周后的总有效率分别为97.97%和85.11%,研究组显著高于对照组(P<0.05)。研究组的外阴瘙痒缓解时间、白带异常缓解时间、粘膜充血缓解时间都显著少于对照组(P<0.05)。研究组治疗8周期间的皮疹、恶心呕吐、腹胀腹痛、发热等不良反应发生率为4.26%,对照组为21.28%,研究组与对照组相比明显降低(P<0.05)。研究组与对照组治疗8周后的血清白细胞介素-6、转化生长因子-β1含量都低于治疗前(P<0.05),研究组治疗8周后的血清白细胞介素-6、转化生长因子-β1含量与对照组相比也显著降低(P<0.05)。结论:中药灌洗配合纳米银抗菌水凝胶在阴道炎患者的治疗中,能提高治疗效果,促进缓解临床症状,减少不良反应,抑制血清白细胞介素-6、转化生长因子-β1的释放。 |
| 英文摘要: |
| Objective: To investigate the effects of herbal lavage combined with nano silver antibacterial hydrogel in the treatment of vaginitis, and observe the occurrence of adverse reactions. Method: From April 2020 to February 2023, 94 cases of patients with vaginitis who were diagnosed and treated at our hospital were selected as the research subjects. Accorded to a 1:1 random number table method, the 94 patients were divided into the study group of 47 cases and the matched group of 47 cases. The matched group were treated with metronidazole, and the study group were treated with herbal lavage combined with nano silver antibacterial hydrogel. Both groups were treated and observed for 8 weeks, and recorded the treatment effect and adverse reactions. Result: After 8 weeks of treatment, the total effective rates of the study group(97.97%) was significantly higher than that of the matched group(85.11%) (P<0.05). The relief time of vulvar itching, abnormal vaginal discharge, and mucosal congestion in the study group were significantly shorter (P<0.05). The incidence of adverse reactions such as rash, nausea and vomiting, abdominal distension and pain, and fever during the 8-week treatment period in the study group were 4.26%, compared to 21.28% in the matched group. The study group showed significant decreased compared to the matched group (P<0.05). The serum interleukin-6 and transforming growth factor- 1β levels after 8 weeks of treatment in two groups were were all lower than before treatment, and the serum interleukin-6 and transforming growth factor- 1β levels after 8 weeks of treatment in the study group were significantly reduced compared to the matched group (P<0.05). Conclusion: Herbal lavage combined with nano silver antibacterial hydrogel can improve the therapeutic effect, promote the alleviation of clinical symptoms, reduce the occurrence of adverse reactions, and inhibit release ofserum interleukin-6 and transforming growth factor-1 in patients with vaginitis. |
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