文章摘要
氯氮平治疗精神分裂症患者更换利培酮后的血常规分析
Analysis of blood routine after risperidone replacement in patients with schizophrenia treated with clozapine
投稿时间:2021-03-31  修订日期:2021-03-31
DOI:
中文关键词: 氯氮平  利培酮  精神分裂症  血常规检查
英文关键词: clozapine  risperidone  schizophrenia  routine blood test
基金项目:
作者单位邮编
金婉薇 云南省精神病医院 650000
冯睿琦 云南省精神病医院 
贾荣 云南省精神病医院 
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中文摘要:
      目的:分析精神分裂症患者长期服用氯氮平后再换用利培酮治疗的血常规检测结果。方法:选取精神分裂症患者120例,服用氯氮平治疗3个月后,更换利培酮治疗,观察分析药物更换前后血常规检测结果的变化。结果:经过3个月氯氮平治疗,以及2个月利培酮治疗,所有研究对象的总PANSS得分、阴、阳性症状得分较治疗前均有明显下降(P < 0.05)。使用氯氮平治疗后有效46例、好转66例、无效8例;更换药物2个月治疗后有效45例、好转68例、无效7例。氯氮平治疗有效率93.33%(112/120),更换利培酮后有效率94.17%(113/120),差异有统计学意义(P < 0.001)。患者在使用两种药物阶段,服药前和服药后2周的RBC和WBC指标都呈下降趋势。换用利培酮治疗2个月后MCHC、PLT水平低于换药前,LYM、MCV水平高于换药前(P < 0.05)。结论:长期应用氯氮平治疗的精神分裂症患者换用利培酮治疗后,血常规水平改善更为明显,可见利培酮治疗效果优于氯氮平。
英文摘要:
      Objective: To analyze the blood routine test results of schizophrenia patients who took clozapine for a long time and then changed to risperidone. Methods: 120 schizophrenic patients were treated with clozapine for 3 months before and after risperidone treatment. The changes of blood routine test results before and after drug replacement were observed and analyzed. Results: After 3 months of clozapine treatment and 2 months of risperidone treatment, the total PANSS scores, negative and positive symptom scores of all subjects were significantly decreased (P < 0.05). After treatment with clozapine, 46 cases were effective, 66 cases were improved, and 8 cases were invalid; after 2 months of drug replacement, 45 cases were effective, 68 cases were improved, and 7 cases were invalid. The effective rate of clozapine was 93.33% (112 / 120), and that of risperidone was 94.17% (113 / 120), the difference was statistically significant (P < 0.001). The RBC and WBC indexes of patients before and 2 weeks after taking the two drugs showed a downward trend. After 2 months of risperidone treatment, the levels of MCHC and PLT were lower than those before dressing change, and the levels of lym and MCV were higher than those before dressing change (P < 0.05). Conclusion: after long-term use of clozapine in the treatment of schizophrenia patients with risperidone treatment, the improvement of blood routine level is more obvious, it can be seen that the effect of risperidone is better than clozapine.
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