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| 苦参凝胶在宫颈环形电切术后的应用观察 |
| The efficacy of Sophora flavescens gel in patients with Cervical Intraepithelial Neoplasia after LEEP |
| 投稿时间：2020-06-30 修订日期：2021-04-02 |
| DOI： |
| 中文关键词: 苦参凝胶 LEEP术 HPV； 宫颈粘连 |
| 英文关键词: Sophora flavescens gel LEEP cervical adhesion HPV |
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| 中文摘要: |
| 摘 要: 目的 探讨苦参凝胶改善宫颈病变患者行宫颈环形电切术（LEEP）的治疗效果。 方法 选择经宫颈细胞学及 HPV-DNA—阴道镜下宫颈活检三阶梯方法确诊的宫颈上皮内瘤变(CIN) II、III级患者 230 例，分为观察组 ( LEEP 术 + 苦参凝胶治疗) 和对照组( LEEP 术治疗) ，监测并比较两组术后阴道流血（排液）量及持续时间、创面愈合时间、宫颈管粘连、HPV转归等指标。结果 观察组术后阴道流血量较对照组明显减少( P ＜ 0．05)；阴道排液时间、宫颈创面愈合时间均较对照组明显缩短( P＜0.05)，观察组宫颈粘连发生率（1.69%:7.14%）明显降低、HPV16、18转阴率明显升高（89.47%:70%）。 结论 LEEP 术治疗后联合应用苦参凝胶，可明显减少Leep术后阴道出血及减少流液的时间，缩短创面愈合时间，减少宫颈粘连，提高HPV16、18转阴且无副作用。 |
| 英文摘要: |
| 【Abstract】Objective To evaluate the efficacy of Sophora flavescens gel in treatment of CIN after loop electrosurgical excision procedure ( LEEP) ． Methods 230 patients who underwent LEEP were selected in this study, all cases were diagnosed as cervical intraepithelial neoplasia ( CINII、III) by pathologist before surgery. According to the simple randomization grouping method，they were divided into two groups．The observation group (118 cases) was given Sophora flavescens gel after LEEP ; the control group (112 cases) was given LEEP only．Vaginal bleeding、 cervical healing、 cervical adhesion、HPV variety were observed during the postoperative follow-up． Ｒesults The observation group had less vaginal blood、drainage , had lower cervical adhesion （1.69% vs 7.14%）, and more positive HR-HPV patients （89.47% vs 70%）converse to negative in observation group (P ＜0.05). Conclusion The using of Sophora flavescens gel after LEEP in ( CINII、III) patients can reduce the postoperative bleeding and drainage, shorten the cervical healing time, reduce the incidence of cervical adhesion, have better clinical outcome in HPV16、18 curing． |
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