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| 保山市13303例女性HPV感染情况分析 |
| Analysis of HPV infection among 13303 women in Baoshan |
| 投稿时间：2020-01-10 修订日期：2020-01-10 |
| DOI： |
| 中文关键词: 人乳头瘤病毒 反向斑点杂交技术 基因分型 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 目的：调查云南省保山市女性宫颈人乳头瘤病毒(HPV)感染现状及基因型分布情况。方法：针对保山市到医院妇科就诊的13303例女性采集宫颈脱落细胞标本,采用反向斑点杂交-基因芯片技术进行HPV基因型检测。结果：HPV感染阳性共检出1161例,阳性率为8.73%,其中高危型感染率8.07%,低危型感染率0.38%,混合感染率0.28%。单一感染率6.98%,多重感染率1.74%。检出的前五位HPV基因型均为高危型,依次为52(2.23%)、16(1.48%)、51(1.07%)、58(1.05%)、68(0.80%)。HPV感染阳性率以16~20岁组最高,为30.8%,61~70岁组其次,为9.56%,呈“U”形分布。结论：保山市女性HPV感染以单一型感染为主,高危型52、16、58、51和68为主要基因型。HPV基因型分布的研究对宫颈癌防治具有重要的指导意义。 |
| 英文摘要: |
| Objective: To investigate the status of cervical papillomavirus (HPV) infection and genotype distribution in women in Baoshan City, Yunnan Province. Methods: A total of 13,303 women who visited the hospital for gynecology in Baoshan City were collected specimens of cervical exfoliated cells, and HPV genotype was detected by reverse dot blot-gene chip technology. Results: A total of 1161 HPV infections were detected with a positive rate of 8.73%, of which the high-risk infection rate was 8.07%, the low-risk infection rate was 0.38%, and the mixed infection rate was 0.28%. The single infection rate was 6.98%, and the multiple infection rate was 1.74%. The top five HPV genotypes detected were all high-risk types, which were 52 (2.23%), 16 (1.48%), 51 (1.07%), 58 (1.05%), and 68 (0.80%). The positive rate of HPV infection was highest in the 16-20 year old group, which was 30.8%, followed by the 61-70 year old group, which was 9.56%, showing a U-shaped distribution. Conclusion: HPV infection in Baoshan women is mainly monotype infection, and high-risk types 52, 16, 58, 51, and 68 are the main genotypes. The study of HPV genotype distribution has important guiding significance for the prevention and treatment of cervical cancer. |
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