| Objective: To explore the clinical effect of Atorvastatin combined with Ezetimibe in the treatment of acute coronary syndrome（ACS）. Methods: A total of 82 patients with ACS admitted to Liaozhong District Orthopedic and Traumatology Hospital from July 1, 2015 to December 31, 2019 were selected as the research objects. According to the random number table method, the subjects were randomly divided into two groups - the control group and the observation group (41 cases in each group). The control group was treated with Atorvastatin, and the observation group was treated with Atorvastatin and Ezetimibe. The blood lipid levels and the incidence of adverse reactions were compared between the two groups. Results: Compared with the control group, the level of TC, TG, LDL-C and HDL-C in the observation group improved better, and the incidence of adverse reactions was lower, the difference was statistically significant (P＜0.05). Conclusion: The combination of atorvastatin and ezetimibe in patients with ACS can effectively reduce the blood lipid level of patients with less adverse reactions and high safety, which is worthy of reference.