| Objective: To observe and analyze the effect of obstetric warm nursing management mode on the effective prevention of postpartum depression. Methods: A total of 108 obstetric patients admitted in our hospital (April 2018 to April 2019) were selected and divided into observation group (using obstetric warm nursing management mode) and control group (using general ward nursing management) according to the digital random table method Model), 54 cases in each group. The incidence of postpartum depression, the rate of postpartum hemorrhage, the rate of neonatal asphyxia, and the self-care ability score of the two groups of obstetric patients were statistically analyzed. Results: The incidence of postpartum depression, the rate of postpartum hemorrhage, and the incidence of neonatal asphyxia in the observation group were 1.9% (1/54), 1.9% (1/54), and 0.0% (0/54), and the control group was 22.2%(12/54), 18.5% (10/54), 14.8% (8/54). The incidence of postpartum depression, postpartum hemorrhage, and neonatal asphyxia were significantly lower in the observation group than in the control group. The differences were statistically significant. Significance (P＜0.05); the self-care ability score of the observation group was (52.3±2.4) points, and the control group was (38.9±4.8) points. The self-care ability score of the observation group was significantly higher than that of the control group. Significance (P＜0.05). Conclusion: The obstetric warm nursing management model can effectively prevent postpartum depression.