| Objective To investigate the clinical effect of perioperative comprehensive nursing intervention for tympanotomy with catheterization in patients with secretory otitis media. Methods From January 2016 to July 2019, 42 patients with otitis media with tympanostomy with tympanostomy were enrolled. The patients were randomly divided into control group (n=20) and observation group according to the operation schedule (n= twenty two). The control group received routine nursing during the perioperative period, and the observation group performed comprehensive comprehensive nursing interventions such as perioperative psychological assessment, emotional intervention, diet nursing, posture nursing, and health education. The surgical outcome, postoperative complications and negative emotional state adjustment were compared between the two groups. Results In the observation group, 17 cases were cured, 4 cases were effective, 1 case was ineffective, and the total effective rate was 95.45%. The control group was cured in 12 cases, effective in 6 cases, and ineffective in 2 cases. The total effective rate was 90%. The observation group was better than the control group. The postoperative air-induced hearing threshold and the air-bone conduction difference were significantly improved in the two groups, but the improvement in the observation group was significantly better than that in the control group. In the observation group, 2 cases of tympanic membrane reaction occurred after operation, and tympanic blood 1 For example, in the control group, there were 5 cases of tympanic membrane reaction, 2 cases of tympanic blood, and 1 case of wound infection. The incidence of postoperative complications in the observation group was significantly lower than that of the control group. The postoperative anxiety and depression scores of the observation group were significantly lower than those of the control group. The differences were statistically significant (P<0.05). Conclusion Perioperative comprehensive nursing intervention for patients with secretory otitis media undergoing tympanotomy with catheterization is performed. The postoperative complication rate is significantly reduced, and the patient's hearing improvement and self-emotion adjustment are promoted to ensure the surgical treatment effect.