Objective To analyze the effect of dyadic coping intervention on the psychological status and quality of life of pregnant women with gestational diabetes mellitus and their spouses. Methods A total of 88 pregnant women with GDM admitted to the Women and Children's Medical Center of Guangzhou Medical University from January 2024 to December 2024 were selected as the research objects. According to the differences in nursing programs, they were divided into the observation group (n=46) and the control group (n=42). The control group was given routine nursing intervention, and the observation group was given dyadic coping intervention. The blood glucose [fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG)], knowledge, attitude and practice questionnaire scores, mental state [self-rating anxiety scale (SAS score), self-rating depression scale (SDS)], and quality of life [World Health Organization Quality of Life-BREF (WHOQOL-BREF)] were compared between the two groups of pregnant women before intervention and 4 months after intervention. The psychological state [self-rating anxiety scale (SAS score), self-rating depression scale (SDS)] and quality of life [World Health Organization Quality of Life-BREF (WHOQOL-BREF)] of spouses of pregnant women before intervention and 4 months after intervention were compared. Results The FPG and 2hPG of pregnant women in the two groups 4 months after intervention were lower than those before intervention, and the observation group was lower than the control group (P<0.05). After 4 months of intervention, the scores of knowledge, attitude and practice questionnaire and WHOQOL-BREF of pregnant women in the two groups were higher than those before intervention, and those in the observation group were higher than those in the control group (P<0.05). The SAS and SDS scores of pregnant women and their spouses in the two groups 4 months after intervention were lower than those before intervention, and those in the observation group were lower than those in the control group (P<0.05). The WHOQOL-BREF scores of the spouses of pregnant women in the two groups 4 months after intervention were higher than those before intervention, and the scores of the observation group were higher than those of the control group (P<0.05). Conclusions Dyation-based coping can improve the psychological status and quality of life of GDM pregnant women and their spouses, improve the level of health knowledge, attitude and practice of pregnant women, and effectively control blood glucose |